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Mississauga covers 288.42 square kilometres (111.36 sq mi) of land, fronting 13 kilometres (8.1 mi) of shoreline on Lake Ontario.
Mississauga is bounded by Oakville and Milton to the west/southwest, Brampton to the north, Toronto to the east, and Lake Ontario to the south/south-east. Halton Hills borders Mississauga's north-west corner. With the exception of the southeast border with Toronto (Etobicoke Creek), Mississauga shares a land border with all previously mentioned municipalities.
Two major river valleys feed into the lake. The Credit River is by far the longest with the heaviest flow, it divides the western side of Mississauga from the central/eastern portions and enters the lake at the Port Credit harbour. The indented, mostly forested valley was inhabited by first nation peoples long before European exploration of the area. The valley is protected and maintained by the Credit Valley Conservation Authority (CVCA).